Naloxone is a fairly stable medication, with a shelf life between 18 months and two years. IN and IM naloxone should be stored between 59 and 86 degrees Fahrenheit, and should be kept away from direct sunlight. In most law enforcement settings, naloxone can be stored in the cab of the vehicle. Alternatively, the medication has been stored with automated external defibrillator (AED) units. Naloxone kits can be maintained by the individual officers, or alternatively issued at roll call and checked in at the end of the shift. Upon expiration, supplies of the medication should be replaced. EVZIO® maintains stability at temperatures of up to 104 degrees for six months.